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KMID : 0829320150180030094
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Korean Journal of Clinical Microbiology
2015 Volume.18 No. 3 p.94 ~ p.97
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Successful Treatment of Fungemia Caused by Cyberlindnera fabianii with Anidulafungin: A Case Report
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Lee Jeong-In
Yu Shi-Nae
Park Jong-Sin
Joo Eu-Jeong
Shin Jong-Hee
Kwon Min-Jung
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Abstract
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Cyberlindnera fabianii (previously known as Hansenula fabianii, Pichia fabianii, and Lindnera fabianii) is a yeast species that forms a biofilm, allowing it to resist azole drugs. In this study, we report a case of fungemia with C. fabianii that was successfully treated with anidulafungin. In this case, the organism was initially misidentified as Candida utilis (with a high probability of 93%, suggesting good identification) using the VITEK 2 yeast identification card (YST ID; bio-Merieux, USA). The species responsible for the patient’s fungemia was correctly identified after sequencing the internally transcribed spacer region and the D1/D2 domain of the large subunit (26S) rDNA gene. The CLSI M27-A3 broth microdilution method
was used to determine the in vitro antifungal activity of anidulafungin and fluconazole against C. fabianii. The MICs of anidulafungin and fluconazole were found to be 0.03 μg/mL and 2 μg/mL, respectively. The patient recovered after 14 days of anidulafungin treatment.
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KEYWORD
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Anidulafungin, Cyberlindnera fabianii
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